תקציר
Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.
| שפה מקורית | אנגלית |
|---|---|
| עמודים (מ-עד) | 622-625 |
| מספר עמודים | 4 |
| כתב עת | Neurology |
| כרך | 36 |
| מספר גיליון | 5 |
| מזהי עצם דיגיטלי (DOIs) | |
| סטטוס פרסום | פורסם - מאי 1986 |
| פורסם באופן חיצוני | כן |