TY - JOUR
T1 - Prophylactic treatment of asthma by an ozone scavenger in a mouse model
AU - Bibi, Haim
AU - Reany, Ofer
AU - Waisman, Dan
AU - Keinan, Ehud
N1 - Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Our hypothesis that inflammation in asthma involves production of ozone by white blood cells and that ozone could be an inflammatory mediator suggests that scavengers of reactive oxygen species (ROS), for example, electron-rich olefins, could serve for prophylactic treatment of asthma. Olefins could provide chemical protection against either exogenous or endogenous ozone and other ROS. BALB/c mice pretreated by inhalation of d-limonene before an ovalbumin challenge exhibited significant attenuation of the allergic asthma symptoms. Diminution of the inflammatory process was evident by reduced levels of aldehydes, reduced counts of neutrophils in the BAL fluid and by histological tests. A surprising systemic effect was observed by decreased levels of aldehydes in the spleen, suggesting that the examination of tissues and organs that are remote from the inflammation foci could provide valuable information on the distribution of the oxidative stress and may serve as guide for targeted treatment.
AB - Our hypothesis that inflammation in asthma involves production of ozone by white blood cells and that ozone could be an inflammatory mediator suggests that scavengers of reactive oxygen species (ROS), for example, electron-rich olefins, could serve for prophylactic treatment of asthma. Olefins could provide chemical protection against either exogenous or endogenous ozone and other ROS. BALB/c mice pretreated by inhalation of d-limonene before an ovalbumin challenge exhibited significant attenuation of the allergic asthma symptoms. Diminution of the inflammatory process was evident by reduced levels of aldehydes, reduced counts of neutrophils in the BAL fluid and by histological tests. A surprising systemic effect was observed by decreased levels of aldehydes in the spleen, suggesting that the examination of tissues and organs that are remote from the inflammation foci could provide valuable information on the distribution of the oxidative stress and may serve as guide for targeted treatment.
KW - Aldehyde biomarkers
KW - Asthma
KW - Respiratory inflammation
KW - Systemic oxidative stress
KW - d-Limonene
UR - http://www.scopus.com/inward/record.url?scp=84922270620&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2014.11.035
DO - 10.1016/j.bmcl.2014.11.035
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 25499435
AN - SCOPUS:84922270620
SN - 0960-894X
VL - 25
SP - 342
EP - 346
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -