Polymorphisms in human H chain V region genes from the V(H)III gene family

M. C. Souroujon, D. B. Rubinstein, R. S. Schwartz, K. J. Barrett

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים


Polymorphisms of the Ig H chain V region (V(H)) genes were examined with probes from the coding and flanking regions of a gene from the largest V(H) gene family, V(H)III. The 5'-flanking probe gave the simplest pattern and revealed the largest number of polymorphic fragments. Analysis of unrelated individuals and of families identified five polymorphic loci. Two alleles were detected for each of two of the loci, whereas a polymorphic band was scored as present or absent for the other three loci. The polymorphic fragments segregated in the expected Mendelian fashion and parental haplotypes could be assigned in all cases. Comparison of the patterns obtained with the flanking and coding region probes suggests that the human V(H)III gene family is highly polymorphic and may contain several hundred V genes. This method, as well as the polymorphisms detected, can be used to investigate the organization and germ-line variation of H chain V genes and their inheritance in normal individuals and in individuals with immunologic disorders.

שפה מקוריתאנגלית
עמודים (מ-עד)706-711
מספר עמודים6
כתב עתJournal of Immunology
מספר גיליון2
סטטוס פרסוםפורסם - 1989
פורסם באופן חיצוניכן

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