Involvement of phosphodiesterases in autoimmune diseases

Keren Mizrachi, Revital Aricha, Tali Feferman, Neta Kela-Madar, Ilana Mandel, Tamar Paperna, Ariel Miller, Avraham Ben-Nun, Sonia Berrih-Aknin, Miriam C. Souroujon, Sara Fuchs

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.

שפה מקוריתאנגלית
עמודים (מ-עד)43-51
מספר עמודים9
כתב עתJournal of Neuroimmunology
כרך220
מספר גיליון1-2
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 30 מרץ 2010

הערה ביבליוגרפית

Funding Information:
Supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (MYASTAID , contract LSHM-CT-2006-037833 ) and The Chief Scientist Office, Israel Ministry of Health .

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