Ofer Reany, Amar Mohite, Ehud Keinan

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים


Synthetic anion carriers are essential for studying natural ion transporters and channels and for useful applications, such as treatment of channelopathies, supramolecular architecture, anion sensing and catalysis. Driven by the hypothesis that replacement of oxygen atoms in bambusurils (BUs) by other heteroatoms could significantly modify their anion binding properties, we calculated their molecular electrostatic potential and found a general trend of anion-affinity: S>O>NH. We confirmed these predictions experimentally by synthesizing semithio- and semiaza-BUs and studying their binding and transport properties. Although all analogs are excellent anion binders, only semithio-bambus[6]uril is an effective transmembrane transporter capable of polarizing lipid membranes through selective anion uniport. Semiaza-BUs exhibit simultaneous accommodation of three anions, linearly positioned along the main symmetry axis, which is reminiscent of natural chloride channels in E. coli.

שפה מקוריתאנגלית
עמודים (מ-עד)449-460
מספר עמודים12
כתב עתIsrael Journal of Chemistry
מספר גיליון3
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - אפר׳ 2018

הערה ביבליוגרפית

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

טביעת אצבע

להלן מוצגים תחומי המחקר של הפרסום 'Hetero-Bambusurils'. יחד הם יוצרים טביעת אצבע ייחודית.

פורמט ציטוט ביבליוגרפי