Combined effects of ATP and its analogs on the membrane permeability in transformed mouse fibroblasts

Ruth Arav, Ilan Friedberg

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Extracellular ATP (0.6 mM) induces a marked decrease in the membrane potential, followed by an increase in cell membrane permeability in transformed mouse fibroblasts. The effects of the ATP analogs, p[CH2]ppA and p[NH]ppA (0.6 mM), on the membrane potential and permeability are much less pronounced. ATP at 0.05 mM has no effect by itself, but markedly increases the analog-induced membrane potential dissipation and permeability. The data suggest that ATP-induced membrane permeation is composed of two processes: One is common to ATP and its analogs and appears to be a receptor-mediated process. The second is unique for ATP, effective even at low concentration (0.05 mM, and might be mediated by cell surface enzymes, for which ATP, but not its analogs, serves as a substrate.

שפה מקוריתאנגלית
עמודים (מ-עד)149-151
מספר עמודים3
כתב עתFEBS Letters
כרך387
מספר גיליון2-3
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 3 יוני 1996

הערה ביבליוגרפית

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Copyright 2017 Elsevier B.V., All rights reserved.

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