Automated breast volumetric sonography compared to magnetic resonance imaging in Jewish BRCA1/2 mutation carriers

Osnat Halshtok Neiman, Zippy Erlich, Eitan Friedman, Arie Rundstein, Anat Shalmon, Yael Servadio, Miri Sklair Levy

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים


Background: Automated breast volumetric sonography (ABVS) is a new technology with various possible applications. Objectives: To compare ABVS and breast magnetic resonance imaging (MRI) in the surveillance of women with a BRCA1/2 gene mutation. Methods: We conducted a prospective study in Jewish female BRCA1/2 mutation carriers who underwent breast MRI and ABVS. The results of both exams performed 6 months apart or less, and relevant clinical data, were reviewed. The BI-RADS results were divided into three subgroups according to subsequent expected management: BI-RADS 1-2 (normal study), BI-RADS 3 (probably benign finding), and BI-RADS 4 and 5 (suspicious findings). BI-RADS 0 and 6 scores were excluded from the study. Distribution of ABVS and MRI BI-RADS scores were compared using McNemar's test, and concordance was calculated using the Cohen kappa test. Results: Overall, 68 women, 40 BRCA1 and 28 BRCA2 mutation carriers, age range 26–69 (mean 44.55 ± 12.1 years), underwent 79 paired ABVS and MRI examinations. McNemar's test calculations showed no significant difference between MRI and ABVS BI-RADS score distribution. Cohen’s kappa test resulted in k = 0.158, an agreement that can be described as only “slight agreement” between both modalities. Of 14 discordant cases there was one cancer, revealed by MRI and not by ABVS performed 6 months prior to MRI. Conclusions: ABVS showed slight agreement with MRI in BRCA1/2 mutation carriers. These preliminary results in a small group of healthy high risk patients suggest that the diagnostic abilities of ABVS are inferior to those of MRI. Further studies encompassing larger groups are needed.

שפה מקוריתאנגלית
עמודים (מ-עד)609-612
מספר עמודים4
כתב עתIsrael Medical Association Journal
מספר גיליון10
סטטוס פרסוםפורסם - אוק׳ 2016

הערה ביבליוגרפית

Publisher Copyright:
© 2016, Israel Medical Association. All rights reserved.

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