A Reversible Light-Driven Biomimetic K+/Na+-Exchanger Controls Cancer Cell Apoptosis

Yaqi Wu, Cong Li, Yanliang Wu, Jiayun Xu, Zhigang Ni, Ofer Reany, Tengfei Yan, Dingcheng Zhu, Junqiu Liu

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Although natural dual-ion exchangers are indispensable for bio-organic functions, developing their artificial counterparts remains nearly unexplored. Herein, this work proposes a novel light-controlled K+/Na+-transport-exchanger TE12, realizing an unprecedented reversible switch between K+- and Na+-transmembrane transport by changing its transport mechanism (channel and carrier). The conformational transformation of the azobenzene moiety in TE12 essentially induces this. The K+/Na+ selectivity of K+-channel Trans-TE12 is as high as 20.3, making it one of the most selective artificial K+-transporters. Moreover, considering the scarcity of artificial Na+-transporters, the Na+-carrier Cis-TE12 with high Na+/K+ selectivity (9.25) represents a breakthrough. Cis-TE12 significantly triggers cell apoptosis by igniting fascinating “Na+ sparks” first observed on cancer cells treated with synthetic channels, while K+-channel Trans-TE12 exhibits low toxicity. Importantly, TE12 can function as a spatiotemporally controllable ion interference therapy, enabling in situ 365 nm light-triggered and 450 nm light-inhibited cell death. This work realizes sophisticated functions in a simplified structure by the “Less is More” design concept. It opens a shortcut toward the future iterative updating of artificial ion transporters to make them better biological analogs and therapeutic agents.

שפה מקוריתאנגלית
כתב עתAdvanced Functional Materials
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםהתקבל/בדפוס - 2024

הערה ביבליוגרפית

Publisher Copyright:
© 2024 Wiley-VCH GmbH.

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