TY - JOUR
T1 - A disease-specific fraction isolated from IVIG is essential for the immunosuppressive effect of IVIG in experimental autoimmune myasthenia gravis
AU - Fuchs, Sara
AU - Feferman, Tali
AU - Meidler, Roberto
AU - Margalit, Raanan
AU - Sicsic, Camille
AU - Wang, Ningshan
AU - Zhu, Kai Yun
AU - Brenner, Talma
AU - Laub, Orgad
AU - Souroujon, Miriam C.
N1 - Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA), The European Commission (EC, No QLG1-CT-2001-10918, QLRT-2001-00225 and LSHN-CT-2006-037833) and The Wood–Byer Foundation.
PY - 2008/2
Y1 - 2008/2
N2 - Intravenous immunoglobulin (IVIG) treatment is beneficially used in autoimmune disorders including myasthenia gravis (MG) although its mode of action and active components are still not fully identified. In an attempt to isolate from IVIG a disease-specific suppressive fraction, IVIG was passed on columns of IgG from rats with experimental autoimmune MG (EAMG) or from MG patients. These chromatographies resulted in depletion of the suppressive activity of IVIG on rat EAMG whereas the minute amounts of IgG fractions eluted from the EAMG- or MG-specific columns retained the immunosuppressive activity of IVIG. These results demonstrate that a minor disease-specific immunoglobulin fraction present in IVIG is essential for its suppressive activity.
AB - Intravenous immunoglobulin (IVIG) treatment is beneficially used in autoimmune disorders including myasthenia gravis (MG) although its mode of action and active components are still not fully identified. In an attempt to isolate from IVIG a disease-specific suppressive fraction, IVIG was passed on columns of IgG from rats with experimental autoimmune MG (EAMG) or from MG patients. These chromatographies resulted in depletion of the suppressive activity of IVIG on rat EAMG whereas the minute amounts of IgG fractions eluted from the EAMG- or MG-specific columns retained the immunosuppressive activity of IVIG. These results demonstrate that a minor disease-specific immunoglobulin fraction present in IVIG is essential for its suppressive activity.
KW - Disease-specific anti-antibodies
KW - Experimental autoimmune myasthenia gravis (EAMG)
KW - IVIG (intravenous immunoglobulin) therapy
KW - Myasthenia gravis (MG)
UR - http://www.scopus.com/inward/record.url?scp=39849095842&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2007.11.020
DO - 10.1016/j.jneuroim.2007.11.020
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C2 - 18178258
AN - SCOPUS:39849095842
SN - 0165-5728
VL - 194
SP - 89
EP - 96
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -