Voltage Sensors Embedded in G Protein-Coupled Receptors

Merav Tauber, Yair Ben-Chaim

Research output: Contribution to journalReview articlepeer-review


Some signaling processes mediated by G protein-coupled receptors (GPCRs) are modulated by membrane potential. In recent years, increasing evidence that GPCRs are intrinsically voltage-dependent has accumulated. A recent publication challenged the view that voltage sensors are embedded in muscarinic receptors. Herein, we briefly discuss the evidence that supports the notion that GPCRs themselves are voltage-sensitive proteins and an alternative mechanism that suggests that voltage-gated sodium channels are the voltage-sensing molecules involved in such processes.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Issue number10
StatePublished - 13 May 2024


  • G protein coupled receptors
  • muscarinic receptor
  • voltage dependence
  • voltage sensor


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