This article introduces the reader to the life and work of Elisabeth Goldschmidt, the founding mother of the field of genetics in Israel. It concurrently strives to uncover the roots and development of genetics in Israel, tracing the crucial transition from classical Drosophila genetics to human genetics and the shift from a Germanic tradition of scientific research to an American one. Goldschmidt's personal biography is inextricably linked to the early stages of genetic research in Israel. The narrative of her life could have been a heroic and inspiring account of a female scientist who 'had it all', had its end been less tragic. Nevertheless, her life was rich, including a path of achievement and trail-blazing coupled with the joy and satisfaction she gleaned from her scientific work.