TORC2-a new player in genome stability

Ronit Weisman, Adiel Cohen, Susan M. Gasser

Research output: Contribution to journalArticlepeer-review


The inhibition of the central growth regulatory kinase TOR, which participates in two complexes, TORC1 and TORC2, has been a focus of metabolic and cancer studies for many years. Most studies have dealt with TORC1, the canonical target of rapamycin, and the role of this complex in autophagy, protein synthesis, and cell growth control. Recent work on TORC2 in budding and fission yeast species points to a conserved role of this lesser-known TOR complex in the survival of DNA damage. In budding yeast, TORC2 controls lipid biosynthesis and actin cytoskeleton through downstream AGC kinases, which are now, surprisingly, implicated in the survival of oxidative DNA damage. Preliminary data from mTORC2 modulation in cancer cells suggest that an extension to human chemotherapy is worth exploring.

Original languageEnglish
Pages (from-to)995-1002
Number of pages8
JournalEMBO Molecular Medicine
Issue number8
StatePublished - Aug 2014


  • Cancer therapies
  • DNA damage
  • MTOR
  • TORC1
  • TORC2


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