TOR links starvation responses to telomere length maintenance

Martin Kupiec; Ronit Weisman

doi:10.4161/cc.20401

TOR links starvation responses to telomere length maintenance

Martin Kupiec, Ronit Weisman

Life Sciences discipline

Research output: Contribution to journal › Review article › peer-review

Abstract

Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.

Original language	English
Pages (from-to)	2268-2271
Number of pages	4
Journal	Cell Cycle
Volume	11
Issue number	12
DOIs	https://doi.org/10.4161/cc.20401
State	Published - 15 Jun 2012

Bibliographical note

Funding Information:
This work was supported by a grant from the Association for International Cancer Research (AICR) to R.W. and grants from the Israel Cancer Research fund and the Israel Cancer Research Foundation to M.K.

Keywords

Gln3
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Starvation
TOR
Telomeres
Wtm1
Yku70
Yku80

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AB - Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.

KW - Gln3

KW - Saccharomyces cerevisiae

KW - Schizosaccharomyces pombe

KW - Starvation

KW - TOR

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TOR links starvation responses to telomere length maintenance

Abstract

Bibliographical note

Keywords

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