Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.
Bibliographical noteFunding Information:
This work was supported by a grant from the Association for International Cancer Research (AICR) to R.W. and grants from the Israel Cancer Research fund and the Israel Cancer Research Foundation to M.K.
- Saccharomyces cerevisiae
- Schizosaccharomyces pombe