The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies

Miry C. Souroujon; Andrew R. Pachner; Sara Fuchs

doi:10.1212/wnl.36.5.622

The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies

Miry C. Souroujon, Andrew R. Pachner, Sara Fuchs

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.

Original language	English
Pages (from-to)	622-625
Number of pages	4
Journal	Neurology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1212/wnl.36.5.622
State	Published - May 1986
Externally published	Yes

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title = "The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies",

abstract = "Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.",

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N2 - Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.

AB - Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.

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The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies

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