The Epigenetics of Neural Learning

Zohar Bronfman, Simona Ginsburg, Eva Jablonka

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Learning, which involves neural plasticity and memory, is manifest at many levels of biological organization: at the single-cell level, at the level of local cell assemblies, and at the system level of dedicated structures such as the hippocampus in mammals. This chapter reviews recent data that focus on the intracellular level and the intercellular synapse-mediated level in the nervous system, showing that several interacting epigenetic mechanisms underlie learning and plasticity. On the basis of the survey of the literature, it shows that there are consistent correlations between global changes in epigenetic regulation and the capacity for learning. The chapter suggests that learning dynamics may be reflected by cumulative epigenetic changes at the neuron level. It discusses the implications of epigenetic mechanisms for the study of the inheritance and evolution of learning. The intracellular epigenetic factors and mechanisms are related to the intercellular neural communication that takes place across the synapses that connect neurons.

Original languageEnglish
Title of host publicationThe Wiley Handbook on the Cognitive Neuroscience of Learning
Number of pages41
ISBN (Electronic)9781118650813
ISBN (Print)9781118650943
StatePublished - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© 2016 John Wiley & Sons, Ltd. All rights reserved.


  • Associative learning
  • Biological organization
  • Epigenetic mechanisms
  • Intercellular neural communication
  • Nervous system
  • Neural plasticity
  • Spatial memory


Dive into the research topics of 'The Epigenetics of Neural Learning'. Together they form a unique fingerprint.

Cite this