Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction

Sara Fuchs; Tali Feferman; Kai Yun Zhu; Roberto Meidler; Raanan Margalit; Ningshan Wang; Orgad Laub; Miriam Souroujon

doi:10.1196/annals.1423.059

Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction

Sara Fuchs, Tali Feferman, Kai Yun Zhu, Roberto Meidler, Raanan Margalit, Ningshan Wang, Orgad Laub, Miriam Souroujon

Life Sciences discipline

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIGs) on immobilized IgG, isolated from rats with EAMG, results in a complete depletion of the suppressive activity of the IVIG. Moreover, the eluate from this EAMG-specific antibody column retains the immunosuppressive activity of IVIG. This study supports the notion that the therapeutic effect of IVIGs is mediated by an antigen-specific anti-immunoglobulin (anti-idiotypic) activity that is essential for its suppressive activity.

Original language	English
Title of host publication	Autoimmunity, Part B Novel Applications of Basic Research
Publisher	Blackwell Publishing Inc.
Pages	550-558
Number of pages	9
ISBN (Print)	1573317098, 9781573317092
DOIs	https://doi.org/10.1196/annals.1423.059
State	Published - Sep 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1110
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Experimental autoimmune myasthenia gravis (EAMG)
Immunotherapy
Intravenous immunoglobulin (IVIG)
Myasthenia gravis (MG)

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10.1196/annals.1423.059

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Fuchs, S., Feferman, T., Zhu, K. Y., Meidler, R., Margalit, R., Wang, N., Laub, O., & Souroujon, M. (2007). Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction. In Autoimmunity, Part B Novel Applications of Basic Research (pp. 550-558). (Annals of the New York Academy of Sciences; Vol. 1110). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1423.059

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keywords = "Experimental autoimmune myasthenia gravis (EAMG), Immunotherapy, Intravenous immunoglobulin (IVIG), Myasthenia gravis (MG)",

author = "Sara Fuchs and Tali Feferman and Zhu, {Kai Yun} and Roberto Meidler and Raanan Margalit and Ningshan Wang and Orgad Laub and Miriam Souroujon",

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Fuchs, S, Feferman, T, Zhu, KY, Meidler, R, Margalit, R, Wang, N, Laub, O & Souroujon, M 2007, Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction. in Autoimmunity, Part B Novel Applications of Basic Research. Annals of the New York Academy of Sciences, vol. 1110, Blackwell Publishing Inc., pp. 550-558. https://doi.org/10.1196/annals.1423.059

Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction. / Fuchs, Sara; Feferman, Tali; Zhu, Kai Yun et al.
Autoimmunity, Part B Novel Applications of Basic Research. Blackwell Publishing Inc., 2007. p. 550-558 (Annals of the New York Academy of Sciences; Vol. 1110).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Fuchs S, Feferman T, Zhu KY, Meidler R, Margalit R, Wang N et al. Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction. In Autoimmunity, Part B Novel Applications of Basic Research. Blackwell Publishing Inc. 2007. p. 550-558. (Annals of the New York Academy of Sciences). doi: 10.1196/annals.1423.059

Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction

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