Protective molecular mimicry in experimental myasthenia gravis

Sin Hyeog Im; Dora Barchan; Tali Feferman; Lily Raveh; Miriam C. Souroujon; Sara Fuchs

doi:10.1016/S0165-5728(02)00069-3

Protective molecular mimicry in experimental myasthenia gravis

Sin Hyeog Im, Dora Barchan, Tali Feferman, Lily Raveh, Miriam C. Souroujon, Sara Fuchs

Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Protein databases were searched for microbial sequences that bear amino acid similarities with identified T- or B-cell epitopes within the human α-subunit of acetylcholine receptor (AChR). One peptide, derived from Haemophilus influenzae, exhibits 50% homology to an identified T-cell epitope of AChR α-subunit. This peptide was shown to have a protective effect in experimental autoimmune myasthenia gravis (EAMG). Pretreatment of rats with the mimicry peptide attenuated the induction and progression of EAMG. These effects were accompanied by a reduced T-cell response to AChR, diminished IL-2, IL-12, IFN-γ and IL-4 levels, as well as decreased humoral response to self-AChR.

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	126
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00069-3
State	Published - 2002

Bibliographical note

Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA), The Association Française contre les Myopathies (AFM), The EC (no. QLG1-CT-2001-01918) and The Abramson Family Foundation.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Acetylcholine receptor (AChR)
Cytokines
Experimental autoimmune myasthenia gravis
Molecular mimicry

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10.1016/S0165-5728(02)00069-3

Cite this

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AU - Fuchs, Sara

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Protective molecular mimicry in experimental myasthenia gravis

Abstract

Bibliographical note

Keywords

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