Protective molecular mimicry in experimental myasthenia gravis

Sin Hyeog Im, Dora Barchan, Tali Feferman, Lily Raveh, Miriam C. Souroujon, Sara Fuchs

Research output: Contribution to journalArticlepeer-review


Protein databases were searched for microbial sequences that bear amino acid similarities with identified T- or B-cell epitopes within the human α-subunit of acetylcholine receptor (AChR). One peptide, derived from Haemophilus influenzae, exhibits 50% homology to an identified T-cell epitope of AChR α-subunit. This peptide was shown to have a protective effect in experimental autoimmune myasthenia gravis (EAMG). Pretreatment of rats with the mimicry peptide attenuated the induction and progression of EAMG. These effects were accompanied by a reduced T-cell response to AChR, diminished IL-2, IL-12, IFN-γ and IL-4 levels, as well as decreased humoral response to self-AChR.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - 2002

Bibliographical note

Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA), The Association Française contre les Myopathies (AFM), The EC (no. QLG1-CT-2001-01918) and The Abramson Family Foundation.

Copyright 2008 Elsevier B.V., All rights reserved.


  • Acetylcholine receptor (AChR)
  • Cytokines
  • Experimental autoimmune myasthenia gravis
  • Molecular mimicry


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