Peptide modulators of protein-protein interactions in intracellular signaling

Miriam C. Souroujon, Daria Mochly-Rosen

Research output: Contribution to journalReview articlepeer-review


Signal transduction cascades involve multiple enzymes and are orchestrated by selective protein-protein interactions that are essential for the progression of intracellular signaling events. Modulators of these protein-protein interactions have been used to dissect the role of individual components of each signaling cascade. We describe several methods that have been developed for the identification of peptides that inhibit the interaction between signaling proteins and hence selectively modulate their functions. Such peptide modulators provide important tools for basic research and have great potential as leads for the development of new classes of therapeutic drugs.

Original languageEnglish
Pages (from-to)919-924
Number of pages6
JournalNature Biotechnology
Issue number10
StatePublished - 1998


  • Protein kinase C
  • Rational design
  • Signal transduction


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