This paper deals with designing a multi-stage production line to satisfy demand that is much greater than the pace of a single machine in most of the production stages. In addition, the pace of machines in a certain stage is typically different than the pace of machines in other stages. Examples of such an environment characterize the production of Printed Circuit Boards (PCBs), cosmetics, food processing, and variety of other industries. The paper discusses the main considerations related to the product life cycle management (PLM), and suggests a strategic, rough-cut solution approach that enables some flexibility during the operation period. After the initial design (setting the number of machines and operators at each stage), the line's operation period may face demand changes that require adjustments. This paper discusses these situations and proposes a solution approach. Simple examples are illustrating both a static initial design, and a dynamic approach for planning changes based on demand realization.