The target of rapamycin (TOR) protein kinase is at the core of growth factor-and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.
Bibliographical noteFunding Information:
Research in the Weisman laboratory is supported by the Open University of Israel grant 31054. Research in the Laribee laboratory is supported by NIH grant R21 CA233028.
Funding: Research in the Weisman laboratory is supported by the Open University of Israel grant 31054. Research in the Laribee laboratory is supported by NIH grant R21 CA233028.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Genomic stability
- Target of rapamycin