Nuclear functions of tor: Impact on transcription and the epigenome

R. Nicholas Laribee, Ronit Weisman

Research output: Contribution to journalReview articlepeer-review


The target of rapamycin (TOR) protein kinase is at the core of growth factor-and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.

Original languageEnglish
Article number641
Pages (from-to)1-24
Number of pages24
Issue number6
StatePublished - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Acetylation
  • Cancer
  • Epigenetics
  • Genomic stability
  • Histones
  • Methylation
  • TORC1
  • TORC2
  • Target of rapamycin
  • Transcription


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