TY - GEN
T1 - Immunosuppression of EAMG by IVIG is mediated by a disease-specific anti-immunoglobulin fraction
AU - Fuchs, Sara
AU - Feferman, Tali
AU - Meidler, Roberto
AU - Margalit, Raanan
AU - Sicsic, Camille
AU - Brenner, Talma
AU - Laub, Orgad
AU - Souroujon, Miriam C.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2008/6
Y1 - 2008/6
N2 - Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIG) on immobilized IgG, isolated from rats with EAMG or from MG patients, results in a depletion of the suppressive activity of the IVIG. Moreover, reconstitution of the activity-depleted IVIG with the eluted minute IVIG fractions that had been adsorbed onto the EAMG- or MG-specific columns recovers the depleted immunosuppressive activity. This study supports the notion that the therapeutic effect of IVIG is mediated by an antigen-specific anti-immunoglobulin (anti-idiotypic) activity that is essential for its suppressive activity.
AB - Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIG) on immobilized IgG, isolated from rats with EAMG or from MG patients, results in a depletion of the suppressive activity of the IVIG. Moreover, reconstitution of the activity-depleted IVIG with the eluted minute IVIG fractions that had been adsorbed onto the EAMG- or MG-specific columns recovers the depleted immunosuppressive activity. This study supports the notion that the therapeutic effect of IVIG is mediated by an antigen-specific anti-immunoglobulin (anti-idiotypic) activity that is essential for its suppressive activity.
KW - Experimental autoimmune myasthenia gravis (EAMG)
KW - Fractionation
KW - Immunotherapy
KW - Intravenous immunoglobulin (IVIG)
KW - Myasthenia gravis (MG)
UR - http://www.scopus.com/inward/record.url?scp=45249088356&partnerID=8YFLogxK
U2 - 10.1196/annals.1405.032
DO - 10.1196/annals.1405.032
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???
C2 - 18567875
AN - SCOPUS:45249088356
SN - 9781573316873
T3 - Annals of the New York Academy of Sciences
SP - 244
EP - 248
BT - Myasthenia Gravis and Related Disorders 11th International Conference
PB - Blackwell Publishing Inc.
ER -