Heterogeneity of Wilson's disease in Israel

J. Passwell, A. Adam, D. Garfinkel, M. Streiffler, B. E. Cohen

Research output: Contribution to journalArticlepeer-review


In a survey in Israel of 50 patients with Wilson's disease, it was found that this disease occurred in all ethnic groups. In the Arab patients there was a significantly early age of onset and the disease followed a more severe course than that in the Jewish patients. The overall sex ratio of patients was nearly 1:1, and genetic analysis of 20 families confirmed an autosomal recessive mode of inheritance. The very similar age of onset and type of disease within sibships and the varying ages of onset noted between the Arab and Jewish patients suggest that the disease is genetically heterogenous.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalIsrael Journal of Medical Sciences
Issue number1
StatePublished - 1977
Externally publishedYes


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