G Protein-Coupled Receptors Regulated by Membrane Potential

Dekel David, Ziv Bentulila, Merav Tauber, Yair Ben-Chaim

Research output: Contribution to journalReview articlepeer-review


G protein-coupled receptors (GPCRs) are involved in a vast majority of signal transduction processes. Although they span the cell membrane, they have not been considered to be regulated by the membrane potential. Numerous studies over the last two decades have demonstrated that several GPCRs, including muscarinic, adrenergic, dopaminergic, and glutamatergic receptors, are voltage regulated. Following these observations, an effort was made to elucidate the molecular basis for this regulatory effect. In this review, we will describe the advances in understanding the voltage dependence of GPCRs, the suggested molecular mechanisms that underlie this phenomenon, and the possible physiological roles that it may play.

Original languageEnglish
Article number13988
JournalInternational Journal of Molecular Sciences
Issue number22
StatePublished - 12 Nov 2022

Bibliographical note

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© 2022 by the authors.


  • G-protein coupled receptors
  • membrane potential
  • voltage dependence
  • voltage sensor


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