DHEA, a neurosteroid, decreases cocaine self-administration and reinstatement of cocaine-seeking behavior in rats

Ravid Doron, Lilach Fridman, Iris Gispan-Herman, Rachel Maayan, Abraham Weizman, Gal Yadid

Research output: Contribution to journalArticlepeer-review


Dehydroepiandrosterone (DHEA), which can act as a potential antidepressant in both animals and humans, appears to lower distress involved with cocaine withdrawal. In fact, a role for neurosteroids in modulation of substance-seeking behavior is becoming increasingly clear. Therefore, we tested the effects of DHEA on the self-administration of cocaine (1 mg/kg/infusion) by rats. At maintenance, a relatively low dose of exogenous DHEA (2 mg/kg; i.p.) attenuated cocaine self-administration after several days of chronic treatment. More than 2 weeks (19 days) of daily DHEA injections were required to decrease the cocaine-seeking behavior of rats to less than 20% of their maintenance levels. DHEA does not seem to decrease cocaine self-administration by increasing the reinforcing properties of the drug, as indicated by a cocaine dose-response determination. After being subjected to extinction conditions in the presence of DHEA, rats demonstrated a minimal response to acute exposure to cocaine (10 mg/kg), which indicated a protective effect of DHEA on relapse to cocaine usage. Our results suggest a potential role for the neurosteroid DHEA in controlling cocaine-seeking behavior, by reducing both the desire for cocaine usage and the incidence of relapse.

Original languageEnglish
Pages (from-to)2231-2236
Number of pages6
Issue number10
StatePublished - 7 Oct 2006
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by a grant from the Israel Science Foundation and from the Israel Anti-Drug Authority to GY. The research reported in this paper was completed as part of the first author’s PhD dissertation, in the Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.


  • Cocaine addiction
  • Dehydroepiandrosterone
  • Neurosteroid
  • Reinforcement
  • Self-administration
  • Withdrawal


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