Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats

Rachel Maayan; Sharon Lotan; Ravid Doron; Maytal Shabat-Simon; Iris Gispan-Herman; Abraham Weizman; Gal Yadid

doi:10.1016/j.euroneuro.2005.10.002

Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats

Rachel Maayan
, Sharon Lotan
, Ravid Doron
, Maytal Shabat-Simon
, Iris Gispan-Herman
, Abraham Weizman
, Gal Yadid

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.

Original language	English
Pages (from-to)	329-339
Number of pages	11
Journal	European Neuropsychopharmacology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/j.euroneuro.2005.10.002
State	Published - Jul 2006
Externally published	Yes

Keywords

Cocaine
Cocaine seeking behavior
Dehydroepiandrosterone (DHEA)
Neurosteroids
Self-administration

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10.1016/j.euroneuro.2005.10.002

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title = "Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats",

abstract = "The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.",

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author = "Rachel Maayan and Sharon Lotan and Ravid Doron and Maytal Shabat-Simon and Iris Gispan-Herman and Abraham Weizman and Gal Yadid",

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doi = "10.1016/j.euroneuro.2005.10.002",

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AU - Maayan, Rachel

AU - Lotan, Sharon

AU - Doron, Ravid

AU - Shabat-Simon, Maytal

AU - Gispan-Herman, Iris

AU - Weizman, Abraham

AU - Yadid, Gal

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AB - The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.

KW - Cocaine

KW - Cocaine seeking behavior

KW - Dehydroepiandrosterone (DHEA)

KW - Neurosteroids

KW - Self-administration

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Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats

Abstract

Keywords

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