Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models

Oron Feinerman; Mor Sofer; Elishai Ezra Tsur

doi:10.1115/FEDSM2018-83362

Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models

Oron Feinerman, Mor Sofer, Elishai Ezra Tsur

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Integrated microfluidic networks are being rapidly deployed in academia and industry for a vast spectrum of applications, ranging from molecular biology to quantum physics. Current design paradigm for microfluidic layouts is typically based on numerical modeling, which is not suitable for rapid prototyping nor parameter driven design. Here, we utilize the hydraulic-electric circuit analogy to propose a circuit analysis methodology and an open-source framework for a parameter- guided design of integrated microfluidic layouts. We provide a method with which a user can intuitively define the circuit's constraints and an algorithm which optimizes the hydraulic layout according to physical constraints. Our algorithm supports valves-integrated design and provides a simulation framework that describes fluid flow with different valves configuration.

Original language	English
Title of host publication	Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics
Publisher	American Society of Mechanical Engineers (ASME)
Volume	3
ISBN (Electronic)	9780791851579
DOIs	https://doi.org/10.1115/FEDSM2018-83362
State	Published - 2018
Externally published	Yes
Event	ASME 2018 5th Joint US-European Fluids Engineering Division Summer Meeting, FEDSM 2018 - Montreal, Canada Duration: 15 Jul 2018 → 20 Jul 2018

Publication series

Name	American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM
Volume	3
ISSN (Print)	0888-8116

Conference

Conference	ASME 2018 5th Joint US-European Fluids Engineering Division Summer Meeting, FEDSM 2018
Country/Territory	Canada
City	Montreal
Period	15/07/18 → 20/07/18

Bibliographical note

Funding Information:
The authors would like to thank Tamara Pearlman-Tsur for her insightful comments. This work was supported by JCT research grant.

Publisher Copyright:
© 2018 American Society of Mechanical Engineers (ASME). All right reserved.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Access to Document

10.1115/FEDSM2018-83362

Cite this

Feinerman, O., Sofer, M., & Tsur, E. E. (2018). Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models. In Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics (Vol. 3). Article V003T21A006 (American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM; Vol. 3). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/FEDSM2018-83362

Feinerman, Oron ; Sofer, Mor ; Tsur, Elishai Ezra. / Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models. Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics. Vol. 3 American Society of Mechanical Engineers (ASME), 2018. (American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM).

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abstract = "Integrated microfluidic networks are being rapidly deployed in academia and industry for a vast spectrum of applications, ranging from molecular biology to quantum physics. Current design paradigm for microfluidic layouts is typically based on numerical modeling, which is not suitable for rapid prototyping nor parameter driven design. Here, we utilize the hydraulic-electric circuit analogy to propose a circuit analysis methodology and an open-source framework for a parameter- guided design of integrated microfluidic layouts. We provide a method with which a user can intuitively define the circuit's constraints and an algorithm which optimizes the hydraulic layout according to physical constraints. Our algorithm supports valves-integrated design and provides a simulation framework that describes fluid flow with different valves configuration.",

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Feinerman, O, Sofer, M & Tsur, EE 2018, Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models. in Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics. vol. 3, V003T21A006, American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM, vol. 3, American Society of Mechanical Engineers (ASME), ASME 2018 5th Joint US-European Fluids Engineering Division Summer Meeting, FEDSM 2018, Montreal, Canada, 15/07/18. https://doi.org/10.1115/FEDSM2018-83362

Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models. / Feinerman, Oron; Sofer, Mor; Tsur, Elishai Ezra.
Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics. Vol. 3 American Society of Mechanical Engineers (ASME), 2018. V003T21A006 (American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Feinerman O, Sofer M, Tsur EE. Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models. In Fluid Machinery; Erosion, Slurry, Sedimentation; Experimental, Multiscale, and Numerical Methods for Multiphase Flows; Gas-Liquid, Gas-Solid, and Liquid-Solid Flows; Performance of Multiphase Flow Systems; Micro/Nano-Fluidics. Vol. 3. American Society of Mechanical Engineers (ASME). 2018. V003T21A006. (American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FEDSM). doi: 10.1115/FEDSM2018-83362

Computer-aided design of valves-integrated microfluidic layouts using parameter-guided electrical models

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