Combined effects of ATP and its analogs on the membrane permeability in transformed mouse fibroblasts

Ruth Arav, Ilan Friedberg

Research output: Contribution to journalArticlepeer-review


Extracellular ATP (0.6 mM) induces a marked decrease in the membrane potential, followed by an increase in cell membrane permeability in transformed mouse fibroblasts. The effects of the ATP analogs, p[CH2]ppA and p[NH]ppA (0.6 mM), on the membrane potential and permeability are much less pronounced. ATP at 0.05 mM has no effect by itself, but markedly increases the analog-induced membrane potential dissipation and permeability. The data suggest that ATP-induced membrane permeation is composed of two processes: One is common to ATP and its analogs and appears to be a receptor-mediated process. The second is unique for ATP, effective even at low concentration (0.05 mM, and might be mediated by cell surface enzymes, for which ATP, but not its analogs, serves as a substrate.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalFEBS Letters
Issue number2-3
StatePublished - 3 Jun 1996

Bibliographical note

Funding Information:
Acknowledgements: This study was partly supported by the Ela Kodesz Institute for Research on Cancer Development and Prevention and by Tel Aviv University.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Extracellular ATP
  • Membrane permeability
  • Membrane potential


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