Abstract
Many characteristics of cancer such as proliferation, survival, progression, immunogenicity, sensitivity, and resistance to therapy are not just endogenously driven by the tumor cells themselves, but are greatly affected by their interaction with the components of their microenvironment. In our recent report, we comprehensively characterized the bacterial content of solid tumors, which is strongly related to tumor type and subtype, largely presenting as metabolically-active and intra-cellular. Our integration with clinical patient data indicates potential avenues of cross-talk between the tumors and their bacterial counterparts paving the way for a deeper understanding of the physiological/biological context of the tumor and how to harness bacteria in therapy settings.
| Original language | English |
|---|---|
| Article number | 1800957 |
| Journal | OncoImmunology |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2020 |
Bibliographical note
Funding Information:This work was supported by the European Research Council [818086]; Israel Science Foundation [2044/17]; International Collaboration Grant from the Jacki and Bruce Barron Cancer Research Scholars? Program, and a partnership of the Israel Cancer Research Fund and City of Hope (COH), as supported by The Harvey L. Miller Family Foundation [0]; Fabrikant-Morse Families Research Fund for Humanity [0]; United States-Israel Binational Science Foundation [2013332].
Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
Keywords
- 16S
- 5R
- Tumor microbiome
- bacteria
- cancer
- microbiome
- tumor microenvironment