Behavioral characterizing of cd24 knockout mouse—cognitive and emotional alternations

Keren Nitzan, Roni Toledano, Shiran Shapira, Nadir Arber, Ravid Doron

Research output: Contribution to journalArticlepeer-review


CD24 is a small, glycophosphatidylinositol-anchored cell surface protein, mostly investigated with respect to cancer, inflammation, and autoimmune diseases. CD24 knockdown or inhibition has been used to test various biochemical mechanisms and neurological conditions; however, the association between CD24 and behavioral phenotypes has not yet been examined. This study aims to characterize cognitive and emotional functions of CD24 knockout mice (CD24−/−)compared with CD24 wild-type mice at three time-points: adolescence, young adulthood, and adulthood. Our results show that CD24−/− mice exhibited better cognitive performance and less anxiety-like behavior compared with WT mice, with no effect on depression-like behavior. This phenotype was constant from childhood (2 months old) to adulthood (6 months old). The results from our study suggest that CD24 may influence important behavioral aspects at the whole-organism level, which should be taken into consideration when using CD24 knockout models.

Original languageEnglish
Article number105
Pages (from-to)1-11
Number of pages11
JournalJournal of Personalized Medicine
Issue number2
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authorsLicensee MDPI, Basel, Switzerland.


  • Anxiety
  • Behavior
  • CD24
  • Cognition
  • Depression


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