Abstract
The inference of genome rearrangement events has been extensively studied, as they play a major role in molecular evolution. However, probabilistic evolutionary models that explicitly imitate the evolutionary dynamics of such events, as well as methods to infer model parameters, are yet to be fully utilized. Here, we developed a probabilistic approach to infer genome rearrangement rate parameters using an Approximate Bayesian Computation (ABC) framework. We developed two genome rearrangement models, a basic model, which accounts for genomic changes in gene order, and a more sophisticated one which also accounts for changes in chromosome number. We characterized the ABC inference accuracy using simulations and applied our methodology to both prokaryotic and eukaryotic empirical datasets. Knowledge of genome-rearrangement rates can help elucidate their role in evolution as well as help simulate genomes with evolutionary dynamics that reflect empirical genomes.
Original language | English |
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Article number | msac231 |
Journal | Molecular Biology and Evolution |
Volume | 39 |
Issue number | 11 |
DOIs | |
State | Published - 1 Nov 2022 |
Bibliographical note
Publisher Copyright:© The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
© The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
Keywords
- approximate Bayesian computation
- genome evolution
- genome rearrangement
- Computer Simulation
- Genomics
- Bayes Theorem
- Genome
- Evolution, Molecular