An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Sergio Pizzighella; Adrienne S. Gordon; Miry C. Souroujon; Daria Mochly-Rosen; Ayala Sharp; Sara Fuchs

doi:10.1016/0014-5793(83)80456-6

An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Sergio Pizzighella, Adrienne S. Gordon, Miry C. Souroujon, Daria Mochly-Rosen, Ayala Sharp, Sara Fuchs

Research output: Contribution to journal › Article › peer-review

Abstract

Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

Original language	English
Pages (from-to)	246-250
Number of pages	5
Journal	FEBS Letters
Volume	159
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(83)80456-6
State	Published - 8 Aug 1983
Externally published	Yes

Keywords

Acetylcholine receptor
Antigenic determinant
Monoclonal antibody
Phosvitin

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10.1016/0014-5793(83)80456-6

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title = "An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin",

abstract = "Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.",

keywords = "Acetylcholine receptor, Antigenic determinant, Monoclonal antibody, Phosvitin",

author = "Sergio Pizzighella and Gordon, \{Adrienne S.\} and Souroujon, \{Miry C.\} and Daria Mochly-Rosen and Ayala Sharp and Sara Fuchs",

year = "1983",

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AU - Pizzighella, Sergio

AU - Gordon, Adrienne S.

AU - Souroujon, Miry C.

AU - Mochly-Rosen, Daria

AU - Sharp, Ayala

AU - Fuchs, Sara

PY - 1983/8/8

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N2 - Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

AB - Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

KW - Acetylcholine receptor

KW - Antigenic determinant

KW - Monoclonal antibody

KW - Phosvitin

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ER -

An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Abstract

Keywords

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