An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Sergio Pizzighella; Adrienne S. Gordon; Miry C. Souroujon; Daria Mochly-Rosen; Ayala Sharp; Sara Fuchs

doi:10.1016/0014-5793(83)80456-6

An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Sergio Pizzighella, Adrienne S. Gordon, Miry C. Souroujon, Daria Mochly-Rosen, Ayala Sharp, Sara Fuchs

Research output: Contribution to journal › Article › peer-review

Abstract

Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

Original language	English
Pages (from-to)	246-250
Number of pages	5
Journal	FEBS Letters
Volume	159
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(83)80456-6
State	Published - 8 Aug 1983
Externally published	Yes

Bibliographical note

Funding Information:
This study was supportedb y grants from the Muscular Dystrophy Association and the Los AngelesC hapter of the MyastheniaG ravis Foundation to SF. and from the NIH and NSF to A.S.G.

Keywords

Acetylcholine receptor
Antigenic determinant
Monoclonal antibody
Phosvitin

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10.1016/0014-5793(83)80456-6

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title = "An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin",

abstract = "Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.",

keywords = "Acetylcholine receptor, Antigenic determinant, Monoclonal antibody, Phosvitin",

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AU - Souroujon, Miry C.

AU - Mochly-Rosen, Daria

AU - Sharp, Ayala

AU - Fuchs, Sara

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N2 - Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

AB - Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

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KW - Antigenic determinant

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KW - Phosvitin

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An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Abstract

Bibliographical note

Keywords

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