An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin

Sergio Pizzighella, Adrienne S. Gordon, Miry C. Souroujon, Daria Mochly-Rosen, Ayala Sharp, Sara Fuchs

Research output: Contribution to journalArticlepeer-review


Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalFEBS Letters
Issue number1-2
StatePublished - 8 Aug 1983
Externally publishedYes

Bibliographical note

Funding Information:
This study was supportedb y grants from the Muscular Dystrophy Association and the Los AngelesC hapter of the MyastheniaG ravis Foundation to SF. and from the NIH and NSF to A.S.G.


  • Acetylcholine receptor
  • Antigenic determinant
  • Monoclonal antibody
  • Phosvitin


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