This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.
Bibliographical noteFunding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (FIGHT-MG , contract # FP7 HEALTH-2009-242-210 ) and The Open University of Israel's Research Fund .
- Autoimmune regulator (Aire)
- Experimental autoimmune encephalomyelitis (EAE)
- Regulatory T cells (Treg)