Age dependent course of EAE in Aire-/- mice

Rina Aharoni; Revital Aricha; Raya Eilam; Ido From; Keren Mizrahi; Ruth Arnon; Miriam C. Souroujon; Sara Fuchs

doi:10.1016/j.jneuroim.2013.06.001

Age dependent course of EAE in Aire^-/- mice

Rina Aharoni, Revital Aricha, Raya Eilam, Ido From, Keren Mizrahi, Ruth Arnon, Miriam C. Souroujon, Sara Fuchs

Life Sciences discipline

Research output: Contribution to journal › Article › peer-review

Abstract

This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

Original language	English
Pages (from-to)	27-34
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	262
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.06.001
State	Published - 2013

Bibliographical note

Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (FIGHT-MG , contract # FP7 HEALTH-2009-242-210 ) and The Open University of Israel's Research Fund .

Keywords

Autoimmune regulator (Aire)
Autoimmunity
Experimental autoimmune encephalomyelitis (EAE)
Regulatory T cells (Treg)
Susceptibility

Access to Document

10.1016/j.jneuroim.2013.06.001

Cite this

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title = "Age dependent course of EAE in Aire-/- mice",

abstract = "This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.",

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author = "Rina Aharoni and Revital Aricha and Raya Eilam and Ido From and Keren Mizrahi and Ruth Arnon and Souroujon, {Miriam C.} and Sara Fuchs",

note = "Funding Information: This research was supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (FIGHT-MG , contract # FP7 HEALTH-2009-242-210 ) and The Open University of Israel's Research Fund .",

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AU - Aharoni, Rina

AU - Aricha, Revital

AU - Eilam, Raya

AU - From, Ido

AU - Mizrahi, Keren

AU - Arnon, Ruth

AU - Souroujon, Miriam C.

AU - Fuchs, Sara

N1 - Funding Information: This research was supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (FIGHT-MG , contract # FP7 HEALTH-2009-242-210 ) and The Open University of Israel's Research Fund .

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N2 - This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

AB - This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

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KW - Autoimmunity

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