At times, a pronounced trough of low barometric pressure extends from equatorial Africa northward, over the Red Sea and the eastern Mediterranean countries, i.e., the Red Sea Trough. The associated weather is usually hot and dry, and consequently the atmosphere becomes conditionally unstable. In cases in which additional moisture is supplied and dynamic conditions become supportive, as the case analyzed here, intense thunderstorms occur, with extreme rain rates, hail and floods. The storm herein analyzed caused extensive damage both in casualties and property and evolved in two main consecutive phases: In the first a Mesoscale Convective System that moved from Sinai northward over Israel dominated, and in the second deep convection was organized mainly along a cold front. Data analysis indicates several synoptic-scale factors that had a supportive effect on the storm formation and intensification: Conditional instability established by the Red Sea trough, mid-level moisture transport from Northern Africa, and upper-level divergence imparted by both polar and subtropical jet streams over the Middle-East. Mesoscale features were further investigated by means of a hydro-meteorological observational analysis with high spatio-temporal resolution using raingauge and radar data, and satellite imagery. It is shown that local factors, particularly topographic effects, play a major role in the evolution, intensity and spatial organization of the convective activity. Our findings support results of a numerical study of another autumn rainstorm associated with the Red Sea trough. In the present case we identify an additional contributing factor, i.e., a mid-latitude upper-level trough that further intensified the storm as it was approaching the Middle-East.