TORC2-a new player in genome stability

Ronit Weisman, Adiel Cohen, Susan M. Gasser

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

The inhibition of the central growth regulatory kinase TOR, which participates in two complexes, TORC1 and TORC2, has been a focus of metabolic and cancer studies for many years. Most studies have dealt with TORC1, the canonical target of rapamycin, and the role of this complex in autophagy, protein synthesis, and cell growth control. Recent work on TORC2 in budding and fission yeast species points to a conserved role of this lesser-known TOR complex in the survival of DNA damage. In budding yeast, TORC2 controls lipid biosynthesis and actin cytoskeleton through downstream AGC kinases, which are now, surprisingly, implicated in the survival of oxidative DNA damage. Preliminary data from mTORC2 modulation in cancer cells suggest that an extension to human chemotherapy is worth exploring.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)995-1002
عدد الصفحات8
دوريةEMBO Molecular Medicine
مستوى الصوت6
رقم الإصدار8
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - أغسطس 2014

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