The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies

Miry C. Souroujon, Andrew R. Pachner, Sara Fuchs

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Experimental autoimmune myasthenia gravis (EAMC) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding gravissite of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)622-625
عدد الصفحات4
دوريةNeurology
مستوى الصوت36
رقم الإصدار5
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - مايو 1986
منشور خارجيًانعم

بصمة

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