Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone

Keyphrases

• Acetaminophen 100%
• Acetaminophen Toxicity 100%
• Amiodarone 100%
• Analgesic 50%
• Antiarrhythmic Agents 50%
• Bioreactor 100%
• Cell Death 50%
• Cell Migration 50%
• Cytochrome P450 (CYP450) 100%
• Cytochrome P450 2E1 (CYP2E1) 50%
• Dose Effect 100%
• Dose-independent 50%
• Drug Mechanism of Action 50%
• Drug Toxicity 50%
• Drug Treatment 50%
• Extrahepatic Tissues 50%
• HeLa Cells 50%
• HepG2 50%
• Human Response 50%
• In Vivo Microenvironment 50%
• Long-term Exposure 50%
• Metabolically Active 50%
• Microprobe 50%
• Microreactor 50%
• Microvesicular Steatosis 50%
• Mitochondrial Complex III 50%
• Mitochondrial Damage 50%
• Mitochondrial Respiration 100%
• Mitochondrial Toxicity 100%
• NAPQI 50%
• Oxygen Dynamics 50%
• Oxygen Gradient 50%
• Oxygen Uptake 100%
• Phase Modulation 100%
• Phospholipidosis 50%
• Pre-incubation 50%
• Repeated Dose Toxicity 50%
• Respiration 50%
• Sensitive Measurement 50%
• Stable Oxygen Isotopes 50%
• Subthreshold 50%
• Time Monitoring 100%
• Time to Onset 50%
• Toxicity Effects 50%
• Transient Losses 50%
• Two-frequency 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Amiodarone 100%
• Analgesic Agent 25%
• Antiarrhythmic Agent 25%
• Ascorbic Acid 25%
• Cosmetics 25%
• CYP2E1 25%
• Dose Toxicity 25%
• Drug Action 25%
• Long Term Exposure 25%
• Mitochondrial Toxicity 100%
• NAPQI 25%
• Paracetamol 100%
• Pharmacotherapy 25%
• Phospholipidosis 25%
• Steatosis 25%

Immunology and Microbiology

• Drug Therapy 50%