Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex

Keyphrases

• Chaperone 20%
• Controlled Processing 20%
• Efficient Processing 20%
• Entry Route 20%
• ER-associated Degradation 20%
• Insulin 20%
• Less Component 20%
• Lumen 20%
• Misfolding 20%
• Mislocalized Proteins 20%
• Naturally Occurring mutations 20%
• Polypeptide 20%
• Post-translational Modification 20%
• Proinsulin 20%
• Proteasomal Degradation 100%
• Quality Control 100%
• Secreted Proteins 20%
• Signal Sequence 40%
• Toxic Events 20%
• Translocated 20%
• Translocon 20%
• Ubiquitin-proteasome System 60%

Biochemistry, Genetics and Molecular Biology

• P97 100%
• Posttranslational Modification 20%
• Preproinsulin 20%
• Proteasome 60%
• Quality Control 100%
• Signal Peptide 40%
• Translocon 20%
• Ubiquitin 60%