Nuclear functions of tor: Impact on transcription and the epigenome

R. Nicholas Laribee, Ronit Weisman

نتاج البحث: نشر في مجلةمقالة مرجعية مراجعة النظراء


The target of rapamycin (TOR) protein kinase is at the core of growth factor-and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.

اللغة الأصليةالإنجليزيّة
رقم المقال641
الصفحات (من إلى)1-24
عدد الصفحات24
مستوى الصوت11
رقم الإصدار6
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - يونيو 2020

ملاحظة ببليوغرافية

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


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