TY - JOUR
T1 - Involvement of phosphodiesterases in autoimmune diseases
AU - Mizrachi, Keren
AU - Aricha, Revital
AU - Feferman, Tali
AU - Kela-Madar, Neta
AU - Mandel, Ilana
AU - Paperna, Tamar
AU - Miller, Ariel
AU - Ben-Nun, Avraham
AU - Berrih-Aknin, Sonia
AU - Souroujon, Miriam C.
AU - Fuchs, Sara
N1 - Funding Information:
Supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (MYASTAID , contract LSHM-CT-2006-037833 ) and The Chief Scientist Office, Israel Ministry of Health .
PY - 2010/3/30
Y1 - 2010/3/30
N2 - We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.
AB - We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.
KW - Experimental allergic encephalomyelitis (EAE)
KW - Experimental autoimmune myasthenia gravis (EAMG)
KW - Multiple sclerosis (MS)
KW - Myasthenia gravis (MG)
KW - Phosphodiesterases (PDE)
UR - http://www.scopus.com/inward/record.url?scp=77649181513&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2009.12.012
DO - 10.1016/j.jneuroim.2009.12.012
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C2 - 20100627
AN - SCOPUS:77649181513
SN - 0165-5728
VL - 220
SP - 43
EP - 51
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -