Intramolecular van der Waals Interactions Challenge Anion Binding in perthio-Bambusurils

Pravat Mondal, Ephrath Solel, Natalia Fridman, Ehud Keinan, Ofer Reany

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء


Bambusurils (BUs) are known to be rigid cavitands that feature an extended, jigger-like conformation, and the BU[6]s strongly bind anions within their hydrophobic cavity. These features are not necessarily shared by the family of perthio-BUs. This study reveals that perthio-BUs assume a compact conformation and perthio-BU[6]s are poor anion binders, crystallizing as anion-free species from solutions containing halide salts. Computational studies show that the equatorial sulfur atoms compete against guest anions for binding with the glycoluril methine groups via strong van der Waals (vdW) attractive interactions. These competitive contacts not only account for the diminished anion-binding of perthio-BUs, but also explain their compact conformation. The semithio- and perthio-BU[4]s form linear coordination polymers with HgII in the solid-state regardless of their intrinsic molecular conformation. The strong involvement of sulfur atoms in intramolecular interactions differentiates the equatorial from the axial (peripheral) heteroatoms, thus offering chemoselective and regioselective transformations.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)13336-13343
عدد الصفحات8
دوريةChemistry - A European Journal
مستوى الصوت25
رقم الإصدار58
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 17 أكتوبر 2019

ملاحظة ببليوغرافية

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


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