GSK-3β inhibition affects singing behavior and neurogenesis in adult songbirds

Etay Aloni, Moran Shapira, Hagit Eldar-Finkelman, Anat Barnea

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

GSK-3 (glycogen synthase kinase-3) is a serine/threonine kinase which is a critical regulator in neuronal signaling, cognition, and behavior. We have previously shown that unlike other vertebrates that harbor both α and β GSK-3 genes, the α gene is missing in birds. Therefore, birds can be used as a new animal model to study the roles of GSK-3β in behavior and in regulating adult neurogenesis. In the present study, we inhibited GSK-3β in brains of adult male zebra finches (Taeniopygia guttata) and accordingly investigated how this inhibition affects behavior and cell proliferation. Our results show that GSK-3 inhibition: (1) affects specific aspects of singing behavior, which might be related to social interactions in birds, and (2) differentially affects cell proliferation in various parts of the ventricular zone. Taken together, our study demonstrates a role of GSK-3β in regulating singing behavior and neuronal proliferation in birds and highlights the importance of GSK-3β in modulating cognitive abilities as well as social behavior.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)233-244
عدد الصفحات12
دوريةBrain, Behavior and Evolution
مستوى الصوت85
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 13 أغسطس 2015

ملاحظة ببليوغرافية

Publisher Copyright:
© 2015 S. Karger AG, Basel.

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