TY - JOUR
T1 - Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats
AU - Maayan, Rachel
AU - Lotan, Sharon
AU - Doron, Ravid
AU - Shabat-Simon, Maytal
AU - Gispan-Herman, Iris
AU - Weizman, Abraham
AU - Yadid, Gal
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/7
Y1 - 2006/7
N2 - The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.
AB - The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.
KW - Cocaine
KW - Cocaine seeking behavior
KW - Dehydroepiandrosterone (DHEA)
KW - Neurosteroids
KW - Self-administration
UR - http://www.scopus.com/inward/record.url?scp=33744540563&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2005.10.002
DO - 10.1016/j.euroneuro.2005.10.002
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C2 - 16309898
AN - SCOPUS:33744540563
SN - 0924-977X
VL - 16
SP - 329
EP - 339
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 5
ER -