TY - JOUR
T1 - Age dependent course of EAE in Aire-/- mice
AU - Aharoni, Rina
AU - Aricha, Revital
AU - Eilam, Raya
AU - From, Ido
AU - Mizrahi, Keren
AU - Arnon, Ruth
AU - Souroujon, Miriam C.
AU - Fuchs, Sara
N1 - Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA) , The Association Francaise Contre les Myopathies (AFM) , The European Commission (FIGHT-MG , contract # FP7 HEALTH-2009-242-210 ) and The Open University of Israel's Research Fund .
PY - 2013
Y1 - 2013
N2 - This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.
AB - This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6. month old mice. In contrast, 2. month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.
KW - Autoimmune regulator (Aire)
KW - Autoimmunity
KW - Experimental autoimmune encephalomyelitis (EAE)
KW - Regulatory T cells (Treg)
KW - Susceptibility
UR - http://www.scopus.com/inward/record.url?scp=84884130253&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2013.06.001
DO - 10.1016/j.jneuroim.2013.06.001
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C2 - 23849800
AN - SCOPUS:84884130253
SN - 0165-5728
VL - 262
SP - 27
EP - 34
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -