A disease-specific fraction isolated from IVIG is essential for the immunosuppressive effect of IVIG in experimental autoimmune myasthenia gravis

Sara Fuchs, Tali Feferman, Roberto Meidler, Raanan Margalit, Camille Sicsic, Ningshan Wang, Kai Yun Zhu, Talma Brenner, Orgad Laub, Miriam C. Souroujon

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Intravenous immunoglobulin (IVIG) treatment is beneficially used in autoimmune disorders including myasthenia gravis (MG) although its mode of action and active components are still not fully identified. In an attempt to isolate from IVIG a disease-specific suppressive fraction, IVIG was passed on columns of IgG from rats with experimental autoimmune MG (EAMG) or from MG patients. These chromatographies resulted in depletion of the suppressive activity of IVIG on rat EAMG whereas the minute amounts of IgG fractions eluted from the EAMG- or MG-specific columns retained the immunosuppressive activity of IVIG. These results demonstrate that a minor disease-specific immunoglobulin fraction present in IVIG is essential for its suppressive activity.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)89-96
عدد الصفحات8
دوريةJournal of Neuroimmunology
مستوى الصوت194
رقم الإصدار1-2
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - فبراير 2008

ملاحظة ببليوغرافية

Funding Information:
This research was supported by grants from The Muscular Dystrophy Association of America (MDA), The European Commission (EC, No QLG1-CT-2001-10918, QLRT-2001-00225 and LSHN-CT-2006-037833) and The Wood–Byer Foundation.

بصمة

أدرس بدقة موضوعات البحث “A disease-specific fraction isolated from IVIG is essential for the immunosuppressive effect of IVIG in experimental autoimmune myasthenia gravis'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا